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NABP NAPLEX Sample Question Answers

Question # 1

A patient with multibacillary leprosy is on dapsone, clofazimine, and rifampin. Which of the following is true regarding the mechanism of action of the medications listed?

A. Dapsone is bacteriostatic because of its inhibitory effects on dihydrofolate reductase
B. Dapsone is bacteriostatic because of its inhibitory effects on myeloperoxidase
C. Clofazimine is bactericidal by directly inhibiting bacterial DNA polymerase
D. Rifampin is bacteriostatic by inhibiting RNA synthesis by blocking DNA-dependent RNA polymerase
E. Rifampin is bactericidal by inhibiting RNA synthesis by blocking DNA-dependent RNA polymerase

Question # 2

In the management of acute ischemic stroke, within how many minutes from symptom onset should alteplase be administered?

A. 3 hours
B. 6 hours
C. 12 hours
D. 24 hours

Question # 3

LN is 84 YOM who is in hospital for a back surgery. His height is 5 feet and 4 inches, weight 85 kg and NKDA.His past medical history includes hypertension, diabetes mellitus, major depression, hypothyroidism and chronic back pain. Post-op day 1, LN’s medication includes Dexamethasone 8mg iv q6h with taper dosing,Ondansetron 4mg iv q6h prn for N/V, Levothyroxine 0.075mg po daily, Lisinopril 10mg po daily, Citalopram 20mg po daily, Docusate sodium / Senna 1 tab po twice a day, Bisacodyl 10mg suppository daily prn for constipation, Famotidine 20mg iv q12hr, Metoclopramide 10mg iv q6h, Metformin 500mg po bid, D51/2NS with 20K at 125mls/hour and Hydromorphone PCA at 0.2mg/hour of basal rate, demand dose 0.1mg. lock-out every 6min, one hour limit 2.2mg/hour. Pertinent morning labs includes serum creatinine 1.4mg/dl, Mg 1.5mg/ dl, K 5.0mmol/L, Na 135mmol/L.LN used 5 on-demand bolus doses from the hydromorphone PCA, how much hydromorphone did the patient get in 24 hours?

A. 10mg
B. 5.3mg
C. 4.8mg
D. 0.5mg
E. 52.8mg

Question # 4

Which of the following is recommended to be monitored in patients on Divalproex Sodium? 

A. CBC
B. Serum ammonia
C. LFT’s
D. Pulmonary function
E. Serum creatinine

Question # 5

Which of the following would be most appropriate to treat infections associated with stenotrophomonas maltophilia?

A. Meropenem
B. Vancomycin
C. Ciprofloxacin
D. Sulfamethoxazole/trimethoprim
E. Ampicillin

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